Beilstein J. Org. Chem.2021,17, 622–629, doi:10.3762/bjoc.17.54
data indicate that GuNA[Me] could be a useful modification for therapeutic antisense oligonucleotides.
Keywords: artificialnucleicacid; duplex-forming ability; oligonucleotide synthesis; Introduction
The efficacy and safety of therapeutic oligonucleotides can be controlled by chemical modifications
, which is a common approach to partially neutralize the polyanionic property of oligonucleotides [15][16][17][18]. In our previous study, a guanidine-bridged nucleic acid (GuNA[H]; Figure 1) bearing a thymine (T) nucleobase was synthesized as a novel artificialnucleicacid for antisense applications [19